Poster - #VH-33834 - Keywords: Hepatocyte Gut-Liver Locsense TEER Caco-2 Microphysiological 3R In-vitro

Innovative Microphysiological Model Using HepatoXcell™ Primary Human Hepatocytes and Locsense Artemis.

Eline K. Geervliet, Marit Zuurveld, Brian Shapiro, Sopheap Sun, Parth Patel, Ruby E. Thamert, Emma Todd, Susan H. Roelofs, and Sujoy Lahiri.
ATCC, Locsense BV and Utrecht University

ABSTRACT:
The development of a highly representative in vitro gut-liver model is essential for improving drug testing accuracy while minimizing the reliance on animal studies. Traditional animal models often fail to fully replicate human physiology, leading to discrepancies in drug metabolism and toxicity predictions.1 A physiologically relevant gut-liver system would provide a more accurate platform to study nutrient absorption, drug bioavailability, and toxicity, ultimately enhancing preclinical research. This approach aligns with the 3Rs principle (Replacement, Reduction, and Refinement), promoting ethical and sustainable alternatives to animal testing while advancing biomedical research and drug development.